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Seeking advice: Erectile Dysfunction & Premature Ejaculation

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d1ce


What's up guys? Finally getting around to posting. This website has been an incredible resource for me and I can not thank Area and it's members enough. With that said, I have a long road ahead of me. I wasn't sure if this was the correct section to post in. Regardless, I will be doing a mind dump of sort as I believe there is a lot of facts that are relevant. No particular order or format at first. Here we go:

- I'm 27 years old suffering from mostly premature ejaculation and varying degrees/bouts of erectile dysfunction.

- I have never been on SSRIs.

- I've been dependent on PDE5i almost the entirety of my sexual lifetime. Cialis has been my pde5 of choice and I first starting having sex consistently around 23.

- PDE5 work but no where near the strength and reliability that they used too. I frequently dose 20mg cialis and still only have 75%-95% erections. I never get those super rock hard diamond cutters that I could rely on cialis ALWAYS giving me.

- I've been an opiate addict since around 21. Got off them and onto buprenorphine several years ago which I've maintained on since.

- Recreationally use Tianeptine and Phenibut each 2-3 times weekly mostly on the weekend. This I feel is one of the key components to my issues and I will expound on this later.

- Learned about edging to extend the pleasure provided by porn and regularly began binging on porn for hours at a time where I would bring myself to the brink of orgasm then stop. This has had a noticeable effect on my ability to get aroused with a real girl, maintain a hard erection, and most certainly caused issues with dopamine/reward system.

- I have been in a new relationship for the past 9 months and my porn usage has dropped significantly so I am making progress on that. Although, I notice if I do slip up just once it has a noticeable effect during actual sex.

- I cruise on testosterone at 200mg/week and cycle in 2-3 month periods of trenbolone at 350mg/week. I utilize arimidex to control estrogen of course and cabergoline whilst on tren to control prolactin.

- Tried proviron at 100mg/day and masteron at 400mg/week and did not notice the slightest difference in libido. The tren on the other hand definitely seems to boost libido but I've never taken it without caber so who knows which is really the cause.

- I had at one point in my life incredible sexual ability. I was able to perform every single time without question. My erection quality would be excellent and I had complete control of my orgasm. This was about a year and a half ago and was during/end of my first tren cycle. Another important fact, during this period I was not using any tianeptine, phenibut, or other recreational drugs. Only maintaining on buprenorphine. I was on cialis though and it worked great at that time.

- I do get morning wood although much rarer without having taken cialis recently and usually only when I have to urinate in the morning. Also, the hardness of the morning wood is very soft and deflates quickly.

- I started taking the tianeptine pre-sex to prevent premature ejaction and it worked very well. I had in essence complete control and could delay ejaculation as long as I wanted all whilst staying reasonable hard UNLESS I overdid the tianeptine.

- I now only take tianeptine recreationally and whist on the effects on HIGH doses my libido is non-existent and ability to get an erection even whilst on cialis is impossible.

- Phenibut in low doses (under 2 grams) seems to HELP my arousal, erection quality, and premature ejaulation. Although, at the doses I need to get a good buzz (5+ grams) it kills my erectile quality even tho mentally I may be horny.

- I seem to suffer a hangover effect the next day from the tianeptine and phenibut where my dick will be incredibly sensitive and controlling orgasm is extremely difficult.

- My definition of premature ejaulation is a little extreme. At the moment, as long as I haven't taken any recreational substances recently I can actually last 15+ minutes without issue BUT that includes some annoying start/stopping during sex to prevent ejaculating. On my good days I can thrust non-stop without those pauses and it makes a world of difference in my and my girlfriends experience.

- I want to get back to that period in which I had COMPLETE control of my orgasm. Only when I want it and that's it. The only way I can do that now is with use of tianeptine/dapoxetine/tramadol presex and that's only if I get the dose right that doesn't end up hurting my erection quality.

- I want to get back to where my erection quality was at or near rock hard. I don't mind relying on the cialis if it WORKED!

I could keep gong on and on but I need to stop here for the moment. From my own observations, my issues seem to arise from neurochemical imbalances/sensitivity from the drug use (+porn) and possibly hormonal as well. I feel a little overwhelmed but am determined to fix this issue WHATEVER it takes! I want to cure this and  no longer have to rely on timing taking something to enjoy sex.

Current stack:
- Testostorone Cyponinate at 200mg/week (split into 3 shots mon/wed/fri to maintain more stable levels).
- Arimidex .5mg @ 3  x week (on injection day).
- Trenbolone @ 50mg day (350mg/week).
- Cabergoline .25mg @ 2 x week.
- Vitamin D 5,000mg
- Fish oil 1000epa+500dha.
- Just started berberine at 500mg twice day to hopefully restore sensitivity to PDE5.
- Sulbutiamine for dopamine at 250mg twice day for dopamine.
- Citrulline + Pine bark extract daily.
- Creatine 5g day.
- I was on telmisartan for blood pressure and I need to get back on it. Helps control BP well and seems to help erectile quality as well.
- Stop taking tianeptine all together. I haven't in over a week now and the further I get away from it the quicker I become aroused and my erection quality improves.
- Reduce phenibut useage.

Area-1255

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Hi D1ce!

Thanks for all the kind words. We are very grateful to have appreciative readers and members who enjoy our work.

Based on what you said it sounds like your prior Opiate use did something bad to your endocrine system. You are on a good stack but Tren and things like that will definitely RAISE your blood pressure. Moreover, Cabergoline should only be used for a maximum of ~2-3 months at a time.

Any longer runs the risk of heart issues.

The Cialis seeming "weaker" over time is probably just your body adapting to the continued inhibition of PDE5. So you could try things that increase NO on other levels. Try adding Garlic + Vitamin C which was demonstrated to increase active NO in humans.

--> https://www.deepdyve.com/lp/elsevier/cellular-effects-of-garlic-supplements-and-antioxidant-vitamins-in-ZgYvrPz9tr
--> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266250/
--> https://www.ncbi.nlm.nih.gov/pubmed/24333161

Hawthorne might help blood pressure as well but you don't need a lot of it.

Stay away from benzo's and opiates. Phenibut too. Sh** will mess your hormones up more.

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d1ce


I see. Couple questions:

- All the following questions carry the same caveat: they must not hurt my libido/erectile ability long term. I don't mind if I absolutely need to take something and during the duration of effect my sexual abilities are dampened just as long as when it wears off/the next day I'm back to normal.

- I NEED something for anxiety. Ideally I could cure it by fixing whatever the underlying issue is and avoiding down regulation by using something more powerful. What would you suggest for this purpose? I can't afford testing at the moment so I'm shooting in the dark a bit. Could it be serotonin, gaba, histamine? Maybe 5-HTP, Sam-E, Bacopa, Ashgawanda, Theanine, Taurine, Kava, Lemon Balm? I will have to have something acutely powerful on hand for situations in which I know anxiety will be high (interviews, talking in front of people, etc) so xanax will have to remain as I only take that about once a week, the propranolol is usually enough. I find the xanax far less impact on my libido if it all compared to opiates/phenibut.

- Quite frankly, I also would something for high energy social situations like partying that won't hurt my libido. This is what I currently get out of Tianeptine/Phenibut. Something that's euphoric. I was thinking maybe switching to amphetamines (adderall, dexedrine, research chem). I'm open to suggestions.

- And finally, the issue with PDE5i. If I wasn't currently sexually active, I would stop taking them all together for at least 3 months whilst taking berberine/+icariin but I need to find another solution in the meantime. Maybe switch to viagra only to avoid long half life of cialis. Slowly taper and introduce icariin. Eventually drop viagra altogether in favor of icariin?

Thanks again.

Area-1255

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Admin / Head Writer
d1ce wrote:I see. Couple questions:

- All the following questions carry the same caveat: they must not hurt my libido/erectile ability long term. I don't mind if I absolutely need to take something and during the duration of effect my sexual abilities are dampened just as long as when it wears off/the next day I'm back to normal.

- I NEED something for anxiety. Ideally I could cure it by fixing whatever the underlying issue is and avoiding down regulation by using something more powerful. What would you suggest for this purpose? I can't afford testing at the moment so I'm shooting in the dark a bit. Could it be serotonin, gaba, histamine? Maybe 5-HTP, Sam-E, Bacopa, Ashgawanda, Theanine, Taurine, Kava, Lemon Balm? I will have to have something acutely powerful on hand for situations in which I know anxiety will be high (interviews, talking in front of people, etc) so xanax will have to remain as I only take that about once a week, the propranolol is usually enough. I find the xanax far less impact on my libido if it all compared to opiates/phenibut.

- Quite frankly, I also would something for high energy social situations like partying that won't hurt my libido. This is what I currently get out of Tianeptine/Phenibut. Something that's euphoric. I was thinking maybe switching to amphetamines (adderall, dexedrine, research chem). I'm open to suggestions.

- And finally, the issue with PDE5i. If I wasn't currently sexually active, I would stop taking them all together for at least 3 months whilst taking berberine/+icariin but I need to find another solution in the meantime. Maybe switch to viagra only to avoid long half life of cialis. Slowly taper and introduce icariin. Eventually drop viagra altogether in favor of icariin?

Thanks again.

Another idea is to try Sub-Q PT-141.
Naps sells it pretty cheap --> https://www.napsgear.org/product_info.php?ref=2522&products_id=437
That would help libido.

Then just continue the Cialis and add in Icariin + continue Berberine.

http://area-1255.forumotion.info

Area-1255

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As far as Anxiety, I would add in KSM-66 (Organic Ashwagandha Extract).

http://area-1255.forumotion.info

d1ce


- I've read about PT-141 quite a bit, that's a interesting recommendation. Would you say it could cause downregulation of any sort?

- I was tempted to order the 60% icariin but for the value it's a terrible proposition. Instead, I saw liftmode offers a 90% extract and as well found this 10% bulk powder from microingrdients: https://www.amazon.com/Strength-Premium-Epimedium-Icariins-Concentrated/dp/B01L2TGSVM/
Doing the math, there would be 10g pure icariin for $24 worth. That's a great value and beats liftmodes higher purity. What do you think?

- Premature ejaculation issue. What do you recommend here? I feel it seems to be serotonin and anxiety related for me. How about Bacopa, Inositol, or St Johns Wort?

I can not thank you enough again. I appreciate the time your taking out of your day.

Area-1255

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Admin / Head Writer
Admin / Head Writer
d1ce wrote:- I've read about PT-141 quite a bit, that's a interesting recommendation. Would you say it could cause downregulation of any sort?

- I was tempted to order the 60% icariin but for the value it's a terrible proposition. Instead, I saw liftmode offers a 90% extract and as well found this 10% bulk powder from microingrdients: https://www.amazon.com/Strength-Premium-Epimedium-Icariins-Concentrated/dp/B01L2TGSVM/
Doing the math, there would be 10g pure icariin for $24 worth. That's a great value and beats liftmodes higher purity. What do you think?

- Premature ejaculation issue. What do you recommend here? I feel it seems to be serotonin and anxiety related for me. How about Bacopa, Inositol, or St Johns Wort?

I can not thank you enough again. I appreciate the time your taking out of your day.

I would stay away from serotonin supplements or anything that raises it.
If you already having issues with libido/erectile function then PRO-SEROTONIN supplements would make it worse.
You likely just have baseline low nitric oxide levels which would cause pretty much all of these issues.

I am doubtful it is coming from anything else because...

  • If it were adrenaline dominance only libido would not be necessarily impacted.
  • Low levels of nitric oxide encourage Anxiety and obsessive behavior in many cases. More specifically, low N.O ignites COMPULSIONS.
  • In your case, you are suffering from a myriad of health issues which are endocrine in nature, but many of which come back to nitric oxide.

So your best bet is to see how that recommendation works.
KSM-66 will help with Premature ejaculation as well.
I would also say to continue/reinitiate edging.
Practicing other forms of P.E as well may help.
PEGym.com is a good community for that.
~Jay

http://area-1255.forumotion.info

d1ce


Got it. So I've looked into the Garlic + Vitamin C studies and found that for the Garlic the Allin/Allicin content is crucial. Surprsingly, this is difficult to find in many garlic supplements but I have found one that appears to be good. Also, they use vitamin c in the form of ester-c. I have ordered the following two:

https://www.amazon.com/gp/product/B000WKSZ7S/
https://www.amazon.com/gp/product/B014K2ZX6E/

I look forward to testing the efficacy of this treatment. I really want to come off the Viagra/Cialis and ultimately, take LESS supplements/chemicals.

Area-1255

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Admin / Head Writer
Admin / Head Writer
d1ce wrote:Got it. So I've looked into the Garlic + Vitamin C studies and found that for the Garlic the Allin/Allicin content is crucial. Surprsingly, this is difficult to find in many garlic supplements but I have found one that appears to be good. Also, they use vitamin c in the form of ester-c. I have ordered the following two:

https://www.amazon.com/gp/product/B000WKSZ7S/
https://www.amazon.com/gp/product/B014K2ZX6E/

I look forward to testing the efficacy of this treatment. I really want to come off the Viagra/Cialis and ultimately, take LESS supplements/chemicals.

I feel you. That's the ideal scenario. I think those will help you. Keep us updated with your progress and make sure you lift weights at least a couple times a week!

http://area-1255.forumotion.info

Area-1255

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Admin / Head Writer

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d1ce


PDE5i Plan:

- Drop Cialis/Viagra cold turkey.
- Replace with Icariin for next couple months.
- Incorporate Berberine and Ginkgo.
- Ensure nitric oxide levels are properly supported by supplementing with Citrulline+Pycnogenol and/or Vitamin C + Garlic. Possibly verify using nitric oxide testing strips.

Other comments:
- Quercetin for cGMP increase/eNOS/nitric oxide, thoughts? Check out this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509250/
- Tongkat Ali, seen tons of info on this one supporting libido in addition to possibly having PDE5i effects. Thoughts?
- As per your article here: https://area1255.blogspot.com/2014/06/signs-and-symptoms-of-low-nmda-receptor.html does that seem appicable to me? Maybe try supplementing D-Aspartic Acid/NMDA. Glutamate Analogues such as "NCG" (couldnt find this one anywhere).

Area-1255

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Admin / Head Writer
Admin / Head Writer
d1ce wrote:PDE5i Plan:

- Drop Cialis/Viagra cold turkey.
- Replace with Icariin for next couple months.
- Incorporate Berberine and Ginkgo.
- Ensure nitric oxide levels are properly supported by supplementing with Citrulline+Pycnogenol and/or Vitamin C + Garlic. Possibly verify using nitric oxide testing strips.

Other comments:
- Quercetin for cGMP increase/eNOS/nitric oxide, thoughts? Check out this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509250/
- Tongkat Ali, seen tons of info on this one supporting libido in addition to possibly having PDE5i effects. Thoughts?
- As per your article here: https://area1255.blogspot.com/2014/06/signs-and-symptoms-of-low-nmda-receptor.html does that seem appicable to me? Maybe try supplementing D-Aspartic Acid/NMDA. Glutamate Analogues such as "NCG" (couldnt find this one anywhere).
That's very interesting.
I've noticed increased flaccid hang from eating Apple's, so that could be from the Quercetin I s'pose.

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