Area-1255

Area-1255's official forum for all of our life extension enthusiasts, bodybuilders, fitness geeks and for those just interested in science and technology.


You are not connected. Please login or register

Phenyl Piracetam increases Dopamine D(1), D(2) and D(3) receptor expression.

View previous topic View next topic Go down  Message [Page 1 of 1]

Area-1255

avatar
Admin / Head Writer
Admin / Head Writer
PHENOTROPIL/Carphedon/Phenyl Piracetam, can help increase dopamine receptors and activity.

http://link.springer.com/article/10.1134%2FS1819712411020048

Abstract
We studied the effects of administration of the new nootropic drug phenotropil (N-carbamoylmethyl-4-phenyl-2-pyrrolidone) at a dose of 100 mg/kg on the quantitative characteristics of dopamine (DA), serotonin (5-HT), glutamate (NMDA), GABA-A (BDZ), and acetylcholine (nACh) receptors in rats using the conditioned passive avoidance task (PAT) under normal conditions and during scopolamine-induced amnesia ex vivo. We found that the cholinolytic drug scopolamine induced a substantial increase in the density (B max) of n-choline receptors in the cortex (by 99% as compared to the control) and NMDA receptors in the hippocampus (by 93%). A single administration of phenotropil (100mg/kg, intraperitoneally) abolished the effect of scopolamine and decreased the number of nACh and NMDA receptors by 46% and 14%, respectively. Phenotropil also abolished the effect of scopolamine on the benzodiazepine receptors and dopamine D1 receptors. Scopolamine decreased the density of D1 receptors by 20% and BDZ receptors by 17%, whereas phenotropil increased the density of receptors by 16% and 25%, respectively. Phenotropil considerably increased the density of dopamine D2 and D3 receptors by 29% and 62%, respectively. Scopolamine also increased the density of D3 receptors by 44% as compared to the control. We did not find any changes in the binding characteristics of 5-HT2 receptors during scopolamine-induced amnesia or during phenotropil treatment. These results demonstrate the role of these receptors in the development of scopolamine-induced amnesia and in neurochemical mechanisms of the anti-amnestic effects of phenotropil.
Original Russian Text © Yu.Yu. Firstova, D.A. Abaimov, I.G. Kapitsa, T.A. Voronina, G.I. Kovalev, 2011, published in Neirokhimiya, 2011, Vol. 28, No. 2, pp. 130–141.

TAGS; Racetams that increase dopamine and dopamine receptors/expression. PHENOTROPIL,CARPHEDON DOPAMINE,NMDA,AMPA,CHOLINERGIC AXIS.

http://area-1255.forumotion.info

View previous topic View next topic Back to top  Message [Page 1 of 1]

Permissions in this forum:
You cannot reply to topics in this forum