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PDE-8 Inhibitors for Super-Charging Testosterone Production!

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The PDE system is a crucial regulator of steroidogenesis, and cAMP is a powerful second messenger that relays the continuance of steroidogenesis. LH levels and LH efficiency is functionally increased by cyclic adenosine monophosphate; including the StAR proteins. Thus the study conducted below proves that by inhibiting the breakdown enzymes that hydrolyze/degrade the messenger cAMP , we may thereby drastically increase testosterone production.

Two methods may be employed to utilize this physiological hack.

DIPYRIDAMOLE (Persantine), a nonselective PDE inhibitor with confirmed PDE8 affinity as well as PDE4 affinity can be purchased at the following link.
https://www.napsgear.org/product_info.php?ref=2522&products_id=416

Butea Superba + Cialis.
http://www.secure-sales.org.uk/clinic/page.cgi?id=inversi0n



cAMP-Specific Phosphodiesterases 8A and 8B, Essential Regulators of Leydig Cell Steroidogenesis


Phosphodiesterase (PDE) 8A and PDE8B are high-affinity, cAMP-specific phosphodiesterases that are highly expressed in Leydig cells. PDE8A is largely associated with mitochondria, whereas PDE8B is broadly distributed in the cytosol. We used a new, PDE8-selective inhibitor, PF-04957325, and genetically ablated PDE8A(−/−), PDE8B(−/−) and PDE8A(−/−)/B(−/−) mice to determine roles for these PDEs in the regulation of testosterone production. PF-04957325 treatment of WT Leydig cells or MA10 cells increased steroid production but had no effect in PDE8A (−/−)/B(−/−) double-knockout cells, confirming the selectivity of the drug. Moreover, under basal conditions, cotreatment with PF-04957325 plus rolipram, a PDE4-selective inhibitor, synergistically potentiated steroid production. These results suggest that the pool(s) of cAMP regulating androgen production are controlled by PDE8s working in conjunction with PDE4. Likewise, PDE8A (−/−)/B(−/−) cells had higher testosterone production than cells from either PDE8A(−/−) or PDE8B(−/−) mice, suggesting that both PDE8s work in concert to regulate steroid production. We further demonstrate that combined inhibition of PDE8s and PDE4 greatly increased PKA activity including phosphorylation of cholesterol-ester hydrolase (CEH)/hormone-sensitive lipase (HSL). CEH/HSL phosphorylation also was increased in PDE8A(−/−)/B(−/−) cells compared with WT cells. Finally, combined inhibition of PDE8s and PDE4 increased the expression of steroidogenic acute regulatory (StAR) protein. Together these findings suggest that both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH/HSL inactive and StAR protein expression low. They also suggest that in order for PDE inhibitor therapy to be an effective stimulator of steroidogenesis, both PDE8 isozymes and PDE4 need to be simultaneously targeted.

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Brazzo


Are there any easy to get pde-8 inhibitors?

Area-1255

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Brazzo wrote:Are there any easy to get pde-8 inhibitors?

The link is listed in the above post.
Arrow https://www.napsgear.org/product_info.php?ref=2522&products_id=416

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DHT>T


Area1255 are u still here? Plz reply? I really need ur help

DHT>T


I want to know what dose of dipyridamole should be used for T boosting? And what are its side effects.. I heard there can be dangerous unstoppable bleeding and blood loss in case of injury. Is it so?

Area-1255

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DHT>T wrote:I want to know what dose of dipyridamole should be used for T boosting? And what are its side effects.. I heard there can be dangerous unstoppable bleeding and blood loss in case of injury. Is it so?

5 or 10 MG of dipyridamole, once or twice a day to start. Work up to 25 MG / day, too much is no good.

Do not take dipyridamole with Ginkgo or any herb with blood thinning properties, even mild
.

You are better off with butea superba versus dipyridamole for safety reasons.

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DHT>T


Thanks... Im the same person who sent u a mail regarding prami..i tried both on mail and forum thinking u may reply on one place..thanku for replieng on both places



Last edited by DHT>T on Thu Oct 20, 2016 5:31 am; edited 1 time in total

DHT>T


Jason aka area1255, im really a great fan of you and your research. I regularly read all your blogposts...i have some questions revolving in my mind from a long time that even google cant answer properly and exactly. So can you plz answer them for me and help me? Thank you so much..u r really awesome... So my questions are 1.) What pharmaceutical drugs can raise hgh or igf1 significantly? 2.) What pharmaceutical drugs can raise dht or 5 alpha reductase? I heard mika who wrote dht manual mentioned it in his ebook but i cant purchase it for money reasons. And my last question 3.) can we increase bone width(not bone density) or thickness with any pharmaceutical after puberty? I mean not longitudinal growth but to increase circumference. I have really small frame, small wrists..is it possible to increase width or cortical bone circumference with anything?

Area-1255

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DHT>T wrote:Jason aka area1255, im really a great fan of you and your research. I regularly read all your blogposts...i have some questions revolving in my mind from a long time that even google cant answer properly and exactly. So can you plz answer them for me and help me? Thank you so much..u r really awesome... So my questions are   1.) What pharmaceutical drugs can raise hgh or igf1 significantly?   2.) What pharmaceutical drugs can raise dht or 5 alpha reductase? I heard mika who wrote dht manual mentioned it in his ebook but i cant purchase it for money reasons.  And my last question 3.) can we increase bone width(not bone density) or thickness with any pharmaceutical after puberty? I mean not longitudinal growth but to increase circumference. I have really small frame, small wrists..is it possible to increase width or cortical bone circumference with anything?

1.) Pramipexole might be an option to raise GH, but it can have some side-effects like initial sedation, Insomnia, nausea etc.
Arrow https://www.ncbi.nlm.nih.gov/pubmed/1350237
2.) Creatine is your best bet to increase DHT, and also eat more fats and protein.
Arrow https://www.ncbi.nlm.nih.gov/pubmed/19741313

3.) Bone width, not so much, to a minor extent with heavy weight lifting and increased intake of minerals, and increasing growth hormones. It's not something that we can do in a short period of time though.

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DHT>T


Will dipyridamole cause hyperandrogenism in every person using it like butea superba did? And dipyridamole is also more potent than butea

DHT>T


Plz reply? Im using 2.5mg of letro two days a week and 20mg dipyridamole daily...can these two will hyperandrogenism in me or high T levels like 1500ngdl or above.i really want that

Area-1255

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DHT>T wrote:Plz reply? Im using 2.5mg of letro two days a week and 20mg dipyridamole daily...can these two will hyperandrogenism in me or high T levels like 1500ngdl or above.i really want that

I can't guarantee you it will get you to those levels, you have to do your own experimentation to find out. In fact, I doubt that using those will get you anywhere past 1000 ng/dl maximum depending on where you are already at. It might not even get you to 900, what are your levels currently?

Do you have a good diet and good exercise regimen? What other supplements are you taking?

2.5 MG of letro may be way too much for you, 1.25 mg may be a safer dose.

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DHT>T


My daily supplement stack consists of 50mg zinc, 5g ashwagandha powder, 5g mucuna pruriens powder, 2g vitamin C, 10000iu vitamin D, 20mg dipyridamole and 0.625mg letro.... I take all these daily.... I think these all combined will boost my T into supraphysiological ranges... I have seen studies where just letro only therapy caused supraphysiological levels of free T and total T... See this.. Just single dose of letro in week caused high end free T https://www.ncbi.nlm.nih.gov/m/pubmed/18426834/ and im not even obese.. https://www.ncbi.nlm.nih.gov/m/pubmed/14623531/ 5 fold increase in T by letro...500% ..on average to 200 to 1200..

Area-1255

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DHT>T wrote:My daily supplement stack consists of 50mg zinc, 5g ashwagandha powder, 5g mucuna pruriens powder, 2g vitamin C, 10000iu vitamin D, 20mg dipyridamole and 0.625mg letro.... I take all these daily.... I think these all combined will boost my T into supraphysiological ranges... I have seen studies where just letro only therapy caused supraphysiological levels of free T and total T... See this.. Just single dose of letro in week caused high end free T https://www.ncbi.nlm.nih.gov/m/pubmed/18426834/   and im not even obese..   https://www.ncbi.nlm.nih.gov/m/pubmed/14623531/   5 fold increase in T by letro...500% ..on average to 200 to 1200..

Well the only way to know for sure is get bloodwork!

Give it a couple weeks. If you feel then you have gotten results, take blood, test levels. Wish you luck man, come back here when you see improvement. Smile

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Area-1255

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@DHT>T, any news?

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