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Link between SSRI antidepressants and SHBG

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1 Link between SSRI antidepressants and SHBG on Sat Mar 05, 2016 8:11 am

seryi7


I have been suffering of PSSD since I stopped taking SSRI's in september 2014. I took the drugs though intermittently, during 1 year. In addition to the changes in dopamine and other neurotransmitters, I think that a reduction on the levels of free testosterone induced by a elevation of SHBG could explain some of the PSSD symptoms. My SHBG is very high and it doesn't seem to come down. I have done 2 blood tests of SHBG and the results are 77 nmol/L and 70 nmol/L. It would be interesting to see if there are more people with a permanent raise of SHBG, so I request people to take a blood test and post the results.

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seryi7 wrote:I have been suffering of PSSD since I stopped taking SSRI's in september 2014. I took the drugs though intermittently, during 1 year. In addition to the changes in dopamine and other neurotransmitters, I think that a reduction on the levels of free testosterone induced by a elevation of SHBG could explain some of the PSSD symptoms. My SHBG is very high and it doesn't seem to come down. I have done 2 blood tests of SHBG and the results are 77 nmol/L and 70 nmol/L. It would be interesting to see if there are more people with a permanent raise of SHBG, so I request people to take a blood test and post the results.

Have you tried anything to remedy the SHBG issue?
Nettles? Tongkat Ali? Proviron?
It's very possible this accounts for a great deal of the PSSD-issues, particularly in those afflicted with decreased sexual desire versus decreased genetial efficiency/arousal.
There is some research to support this.

http://www.mental-health-today.com/rx/testos.htm
http://www.ncbi.nlm.nih.gov/pubmed/16517449
http://www.peaktestosterone.com/Testosterone_Prozac.aspx
http://www.ncbi.nlm.nih.gov/pubmed/10368794
http://www.cell.com/trends/endocrinology-metabolism/references/S1043-2760(00)00333-7

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seryi7


I have tried tongkat ali but it didn't work. I don't want to use nettles because I have read that it block 5 alpha reductase. About proviron, I haven't used it because I think it can reduce my testosterone production. I would like to use danazol but as in the case of proviron it can shut down hpta. If I take danazol the drop in shbg levels is permanent?

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seryi7 wrote:I have tried tongkat ali but it didn't work. I don't want to use nettles because I have read that it block 5 alpha reductase. About proviron, I haven't used it because I think it can reduce my testosterone production. I would like to use danazol but as in the case of proviron it can shut down hpta. If I take danazol the drop in shbg levels is permanent?

If you use the nettle {HP; "High Potency"} EXTRACT then you won't run into those Issues..statistically, it's more likely to loosen up the DHT from SHBG thus increasing free T & DHT. It's mechanism is less clear than some others but it is reported to work for libido issues.
Proviron is VERY VERY *Minimally* Suppressive - it also has anti-E effects and aromtase inhibition remains a very good way to suppress SHBG as well..in this case, Adex (Arimidex, Anastrzole) is most fit and it doesn't bottom out E2-levels like Letro.

So you don't run into the joint / bone issues with Adex .


Here's a good write-up... http://area1255.blogspot.com/2015/02/natural-vs-pharmaceutical-aromatase.html

Also check out these links.
http://www.ncbi.nlm.nih.gov/pubmed/2892728
http://www.steroidology.com/proviron-all-you-need-to-know/
http://united-muscle.com/archive/index.php/t-2158.html
https://forums.t-nation.com/t/experiences-with-proviron-dht/142618

Naps Proviron is pretty decent price if you wanna take a look.

https://www.napsgear.org/product_info.php?ref=2522&products_id=120

https://www.napsgear.org/product_info.php?ref=2522&products_id=6877


Naps arimidex for future Reference..
https://www.napsgear.org/product_info.php?ref=2522&products_id=7083

Int J Gynaecol Obstet. 1988 Feb;26(1):121-8.
The effect of mesterolone on sperm count, on serum follicle stimulating hormone, luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic men.
Varma TR1, Patel RH.
Author information
Abstract
Two hundred fifty subfertile men with idiopathic oligospermia (count less than 20 million/ml) were treated with mesterolone (100-150 mg/day) for 12 months. Seminal analysis were assayed 3 times and serum follicle stimulating hormone (FSH) luteinizing hormone (LH) and plasma testosterone were assayed once before treatment and repeated at 3, 6, 9 and 12 months after the initiation of treatment. One hundred ten patients (44%) had normal serum FSH, LH and plasma testosterone, 85 patients (34%) had low serum FSH, LH and low plasma testosterone. One hundred seventy-five patients (70%) had moderate oligospermia (count 5 to less than 20 million/ml) and 75 patients (30%) had severe oligospermia (count less than 5 million/ml). Seventy-five moderately oligospermic patients showed significant improvement in the sperm density, total sperm count and motility following mesterolone therapy whereas only 12% showed improvement in the severe oligospermic group. Mesterolone had no depressing effect on low or normal serum FSH and LH levels but had depressing effect on 25% if the levels were elevated. There was no significant adverse effect on testosterone levels or on liver function. One hundred fifteen (46%) pregnancies resulted following the treatment, 9 of 115 (7.8%) aborted and 2 (1.7%) had ectopic pregnancy. Mesterolone was found to be more useful in patients with a sperm count ranging between 5 and 20 million/ml. Those with severe oligospermia (count less than 5 million) do not seem to benefit from this therapy.
PMID: 2892728 [PubMed - indexed for MEDLINE]

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seryi7


I will take into account to use proviron and nettles... but could you tell me if I use danazol the drop in shbg will be permanent?

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seryi7 wrote:I will take into account to use proviron and nettles... but could you tell me if I use danazol the drop in shbg will be permanent?

No, you can't permanently abolish SHBG in humans.

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